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Oncotarget News

Study Identifies Key Genetic Alterations and Biomarker for Blastic Plasmacytoid Dendritic Cell Neoplasm

July 7, 2025

Our findings demonstrate that the mutational landscape of BPDCN is similar to that observed in other myeloid neoplasms, and we identified CCDC50 as a potential biomarker for this disease.”BUFFALO,... read more

Oncotarget

New Drug Combination Redefines First-Line Treatment for Advanced Urothelial Cancer

July 1, 2025

Recent developments have introduced promising therapies, notably the combination of enfortumab vedotin with pembrolizumab, which is now recommended as the first-line therapy following the EV-302 trial results.”BUFFALO, NY - July... read more

Oncotarget

HER2-Mutated NSCLC in Brazil Shows Diverse Genetic Patterns and Treatment Gaps

June 27, 2025

Our findings highlight the molecular diversity and diagnostic challenges of HER2-mutated NSCLC in underrepresented populations, emphasizing the need for comprehensive molecular profiling and expanded access to targeted therapies.”BUFFALO, NY -... read more

Oncotarget

WIN International Molecular Tumor Board Recommends Tailored Treatment for Advanced Colorectal Cancer

June 24, 2025

This case emphasizes the critical role of comprehensive molecular profiling and personalized therapeutic approaches in managing complex mCRC.”BUFFALO, NY - June 24, 2025 – A new precision oncology paper was published... read more

Oncotarget

CHEK2 Identified as a Potential Target to Improve Immunotherapy in Solid Tumors

June 20, 2025

Taken together, CHEK2 expression has the potential to predict resistance or non-response to immunotherapy.”BUFFALO, NY - June 20, 2025 – A new review was published in Volume 16 of Oncotarget on... read more

Oncotarget

Rare Pancreatic Cancer Patients Show Strong Response to Immunotherapy

June 17, 2025

Our case series adds to published data from early-phase trials supporting the promise of immunotherapy in some patients with PC.”BUFFALO, NY - June 17, 2025 – A new research paper was... read more

Oncotarget

Balancing Time, Cost, and Quality in Cardio-Oncology Care

June 13, 2025

The unattainable triangle, also known as the iron triangle or triple constraint, traditionally applied in business as a model for balancing time, cost, and quality, offers valuable insight into the... read more

Oncotarget

Rare Non-Small Cell Lung Cancer with Brain Metastases Responds to Amivantamab Monotherapy

June 11, 2025

This case challenges current paradigms, demonstrating that amivantamab monotherapy can effectively target rare EGFR mutations, achieve durable extracranial and CNS disease control, and potentially overcome blood-brain barrier limitations.”BUFFALO, NY -... read more

Oncotarget

Oncotarget Sponsors Open Access Team in 2025 Ride for Roswell

June 10, 2025

Impact Journals, the publisher of Oncotarget, is once again proudly sponsoring the Open Access Team in the annual Ride for Roswell.BUFFALO, NY — June 10, 2025 — The Ride for Roswell,... read more

Oncotarget

Cigarette Smoke and DNA Repair Deficiency Drive Lung Cancer Development

June 9, 2025

In this study, we investigated the interplay between cigarette smoke, DNA damage and repair, focusing on the Nucleotide Excision Repair (NER) protein Xeroderma Pigmentosum Group C (XPC).”BUFFALO, NY - June... read more