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The Double-Edge Sword of CRISPR Application for In Vivo Studies

November 28, 2023

The Achilles’ heel of CRISPR application is the delivery of sgRNA/Cas9 to the desired tissues.”BUFFALO, NY- November 28, 2023 – A new editorial paper was published in Oncotarget's Volume... read more

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Targeting Ras With Protein Engineering

November 27, 2023

While Ras’s relationship to cancer has been long established [37], it has been considered an undruggable target for many years.”BUFFALO, NY- November 27, 2023 – A recent review paper... read more

Figure 2: The spectrum of pathogenic variants in the early-onset breast cancer cohort.

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Genetic Predisposition to Early Breast Cancer in Kazakh Women

November 22, 2023

Our study may reveal previously uncharacterized population-specific variants that may increase the risk of BC in the Kazakh population.”BUFFALO, NY- November 22, 2023 – A new research paper was published... read more

Figure 1: Chromatin landscape of the glioma GWAS locus rs55705857 in the melanocyte lineage.

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Predicting the Molecular Functions of Regulatory Genetic Variants Associated With Cancer

November 20, 2023

Effectively integrating these rich resources with GWAS results will continue to help prioritize causative inherited genetic variants and improve our molecular understanding of disease etiology [...]”BUFFALO, NY- November 20, 2023 –... read more

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Obesity Paradox and Lung Cancer, Metformin-based Therapeutic Opportunity?

November 15, 2023

These findings suggest a strong sensitization by the addition of metformin in obese population, suggesting that biochemical and molecular differences influence the treatment response.”BUFFALO, NY- November 15, 2023 – A... read more

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C/EBPβ Cooperates With MYB to Maintain the Oncogenic Program of AML Cells

November 13, 2023

This makes C/EBPβ an interesting pro-oncogenic player in AML, worthy of further studies.”BUFFALO, NY- November 13, 2023 – A new editorial perspective was published in Oncotarget's Volume 14 on... read more

Figure 1: Graphical illustration of the main findings from Pfeiffer et al., Cancer Research, 2022. Combined Inhibition of SHP2 and Mutated RTKs Prevent Acquired Resistance in Leukemia

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Combined Inhibition of SHP2 and Mutated RTKs Prevent Acquired Resistance in Leukemia

November 8, 2023

In summary, this study reveals a molecular escape mechanism of mutated RTK-driven leukemic cells from SHP2 allosteric inhibition [...]”BUFFALO, NY- November 8, 2023 – A new editorial paper was published in... read more

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The Uncharted Role of HER2 Mutant Alleles in Breast Cancer

November 6, 2023

Our research study has demonstrated that poziotinib is highly potent in neratinib-resistant HER2 L755S lobular and ductal breast cancer models [...].”BUFFALO, NY- November 6, 2023 – A new editorial paper was... read more

Figure 1: An overview of the endocannabinoid pathway and molecules tested in this study. breast cancer

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FAAH Inhibition Ameliorates Murine Breast Cancer

November 1, 2023

Besides being the most common, breast cancer is also a leading cause of cancer death in women worldwide.”BUFFALO, NY- November 1, 2023 – A new research paper was published in... read more

Figure 1: Mechanisms involved in regulation of tumor progression by neutrophil PAD4.

Oncotarget

Neutrophil PAD4: How Does it Function in Cancer Beyond Promoting NETosis?

October 30, 2023

This will open a novel therapeutic approach for targeting PMN-MDSC in cancer.”BUFFALO, NY- October 30, 2023 – A new editorial paper was published in Oncotarget's Volume 14 on March 24,... read more