Category: Oncotarget

Oncotarget News

Figure 7: Effects of TGF-β receptor inhibitor EW7197 with and without TGF-β1 for LSR, TRIC, OCLN, and CLDN-2 in human lung epithelial cells (HLE) cells with and without 10% FBS.

Downregulation of Angulin-1/LSR Induces Malignancy in Lung Adenocarcinoma

March 29, 2023

In the present study, we found that downregulation of angulin-1/LSR induced malignancy via upregulation of EGF-dependent CLDN-2 and TGF-β-dependent cell metabolism in human lung adenocarcinoma.” BUFFALO, NY-... read more

Figure 5: NSL-YHJ-2-27 suppresses cancer cell migration and invasion.

Oncotarget

Oncotarget | Polyisoprenylated Cysteinyl Amide Inhibitors Deplete G-Proteins in Cancer Cells

March 28, 2023

mutations in G-proteins have been associated in the progress of several cancers [...]” BUFFALO, NY- March 28, 2023 – A new research paper was published in Oncotarget's Volume 14 on March... read more

Figure 6: Overexpression of GPC1 increases proliferation of T24 cells.

Oncotarget

Oncotarget | Attenuation of Cancer Proliferation by Suppression of Glypican-1

March 22, 2023

This study was designed to increase the knowledge on the potential of GPCs and in particular GPC1 as a biomarker in cancer diagnosis and prognosis.” BUFFALO, NY- March 22,... read more

Oncotarget

Oncotarget | Unlocking the Potential of Molecular-Driven Stratification of Osteosarcoma

March 20, 2023

We are very enthusiastic about these initiatives and the recent rate of discoveries in OSA, and hopeful that they will bring actionable targets for OSA.” BUFFALO, NY- March 20,... read more

Figure 1: Mechanism of action of MTAP along with downstream effects from its loss.

Oncotarget

Oncotarget | MTAP Loss in Metastatic Breast Cancer Patients: Genomic Landscape

March 14, 2023

In breast cancer, MTAP downregulation activates ornithine decarboxylase (ODC) which in turn leads to formation of putrescine which promotes tumor migration, invasion and angiogenesis [15].” BUFFALO, NY- March 14,... read more

Figure 6: Synergistic/antagonistic combinations.

Oncotarget

Oncotarget | Selective Protection of Normal Cells From Chemotherapy, While Killing Drug-Resistant Cancer Cells

March 13, 2023

Selective protection of normal cells may transform therapy of cancer.” BUFFALO, NY- March 13, 2023 – A new review paper was published in Oncotarget's Volume 14 on March 11, 2023,... read more

Oncotarget

Oncotarget | Mitochondria Engage the Integrated Stress Response to Promote Tumor Growth

March 8, 2023

Overall, this research proposes a new paradigm on how AR-independent PCa can drive tumor traits by exploiting mitochondrial signaling pathways [...]” BUFFALO, NY- March 8, 2023 – A new editorial paper... read more

Oncotarget

Oncotarget | HALP Score: Prognostic Ability in Cancers – A Literature Review

March 6, 2023

In the last several years, the Hemoglobin, Albumin, Lymphocyte, Platelet Score (HALP) has emerged in the literature as a new prognostic biomarker [...]” BUFFALO, NY- March 6, 2023 – A new... read more

Oncotarget

Oncotarget | Unveiling the Non-canonical Functions of EZH2 in Prostate Cancer

March 3, 2023

In summary, both articles by Yi et al. emphasized the significance of non-canonical functions of EZH2 during PCa [prostate cancer] development [...]” BUFFALO, NY- March 3, 2023 – A new editorial... read more

Figure 1: Comparison of progression-free survival (A) and overall survival (B) between children (

Oncotarget

Oncotarget | WNT-pathway Medulloblastoma: What Constitutes Low-risk and How Low Can One Go?

February 27, 2023

The definition of low-risk WNT-pathway medulloblastoma may need to be refined in light of recent clinical data and newer biological information.” BUFFALO, NY- February 27, 2023 – A new research... read more