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Histology image of flame shaped plasma cells promoting multiple myeloma condition understanding

Targeted Therapies Drive Long-Term Decline in Multiple Myeloma Mortality in the U.S.

April 29, 2026

Multiple myeloma (MM), the second most common hematologic malignancy in the United States, has undergone transformative therapeutic innovation over the past five decades.”BUFFALO, NY - April 29, 2026 – A new... read more

Oncotarget

Epigenetic Dysregulation of PDX1 Drives Prostate Cancer Progression

April 15, 2026

Aberrant DNA methylation changes lead to abnormal gene expression that contributes to the development and progression of prostate cancer (PCa).”BUFFALO, NY - April 15, 2026 – A new research paper was... read more

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Adjuvant PD-1/PD-L1 Inhibitors Show Efficacy but Highlight Safety Considerations in Solid Cancers

April 7, 2026

Programmed cell death protein-1 (PD-1) and programmed death ligand-1 (PD-L1) inhibitors are widely used in cancer treatment.”BUFFALO, NY - April 7, 2026 – A new research paper was published in Volume... read more

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The SCD1 Inhibitor Aramchol, Regorafenib, and Metformin Combine to Kill Uveal Melanoma Cells

March 31, 2026

Aramchol and metformin interacted to modestly enhance cell death in PDX UM cells, though this was less than that caused by the combination of aramchol and the multi-kinase inhibitor regorafenib.”... read more

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CREB5 Linked to Stem Cell-Like Programs That Promote Prostate Cancer Progression

March 24, 2026

We determined that CREB5 is a key regulator of basal and SCL transcriptional programs and tumor-forming phenotypes in PC.”BUFFALO, NY - March 24, 2026 – A new research paper was published... read more

Oncotarget

Colorectal Cancer Survival Predicted by AI Using Clinical and Molecular Features

December 17, 2025

The clinical and biological features proposed here in conjunction with ML can improve the interpretation of CRC mechanisms and predict patient survival.”BUFFALO, NY - December 17, 2025 – A new research... read more

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Lower LRIG1 Expression Linked to Aggressive Gliomas

November 12, 2025

Our results reinforce suggestions that LRIG1-3 could function as diagnostic markers and therapeutic targets in the treatment of gliomas.”BUFFALO, NY - November 12, 2025 – A new research paper was published... read more