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Figure 7: Immunological effect of Nerofe and DOX: CT26 murine model showing the immunological effect of Nerofe, DOX, and their combined treatment.

Transformation of Immunosuppressive mtKRAS Tumors Into Immunostimulatory Tumors by Nerofe and Doxorubicin

July 5, 2023

we demonstrated that the combination of Nerofe and DOX exerts a synergistic effect during mCRC treatment [...]”BUFFALO, NY- July 5, 2023 – A new research paper was published in Oncotarget's Volume... read more

Figure 1: Upon activation by the specific agonist LY500307 ERβ binds to estrogen receptor binding elements (ERE) in regulatory regions of GPR141 and ELMO1 genes and suppresses their transcription, which in turn leads to diminished RhoC activation, reduced actin-based cell migration and metastasis.

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ERβ as a Mediator of Estrogen Signaling in Inflammatory Breast Cancer

July 3, 2023

The mechanism of the anti-metastatic activity of ERβ was investigated [...]”BUFFALO, NY- July 3, 2023 – A new editorial paper was published in Oncotarget's Volume 14 on June 12, 2023, entitled, “... read more

Figure 1: Mechanisms of MCL-1 inhibitor-induced MCL-1 protein upregulation, stability, and induction of apoptosis.

Oncotarget

Decoding the Mechanism Behind MCL-1 Inhibitors: A Pathway to Understanding MCL-1 Protein Stability

June 28, 2023

Taken together, the study provides novel insights into the regulation of MCL-1 expression by MCL1i, associated molecular changes and their implications.”BUFFALO, NY- June 28, 2023 – A new editorial paper... read more

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Ride for Roswell 2023: Team Open Access Recap

June 26, 2023

In a remarkable achievement, Oncotarget and Team Open Access contributed to an impressive total raise of $5.6 million (and the amount continues to grow) for cancer research through the... read more

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DPDT Anticancer Activity in Human Colon Cancer HCT116 Cells

June 26, 2023

Altogether, our results show that DPDT preferentially targets HCT116 colon cancer cells likely through DNA topoisomerase I poisoning.”BUFFALO, NY- June 26, 2023 – A new research paper was published in... read more

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Why We Ride: Misha Pletnikov

June 23, 2023

My name is Misha Pletnikov, I am chair of the department of physiology and biophysics in the Jacobs School of Medicine and Biomedical Sciences of the University at Buffalo. I... read more

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Targeting GITR in cancer immunotherapy – there is no perfect knowledge

June 21, 2023

the experience with GITR targeting in patients may inform the development of either novel or next-generation immunotherapy approaches.”BUFFALO, NY- June 21, 2023 – A new research perspective was published in... read more

Figure 4: Variable changes in phosphorylation of S6 kinase 1 was observed in both cohorts. metformin

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Metformin’s Role in Preventing Metabolic Syndrome during Androgen Deprivation Therapy: A Phase II Study

June 20, 2023

we found no impact of the addition of metformin to [androgen deprivation] therapy on risk of metabolic syndrome associated with castration therapy and no additional anti-tumor effects.”BUFFALO, NY- June... read more

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Oncotarget Sponsors 2023 Ride for Roswell

June 19, 2023

Oncotarget's publisher, Impact Journals, is sponsoring Team Open Access in the annual cycling event to end cancer: The Ride for Roswell. This fundraiser is hosted by Roswell Park Comprehensive Cancer... read more

Figure 1: Proposed pathway of ACSL4-mediated stimulation of quadruple negative breast cancer cells

Oncotarget

ACSL4: Biomarker, Mediator and Target in Quadruple Negative Breast Cancer

June 14, 2023

ACSL4 has been demonstrated to play a pivotal role in both normal physiology as well as in a variety of disease states, including breast and other cancers.”BUFFALO, NY- June... read more