Tag: Breast Cancer

Nanobody Inhibits Metastasis of Breast Tumor Cells to Lung in Mice

August 15, 2024

“In the present study we describe the development of an inhibitory nanobody directed against an extracellular epitope present in the native V-ATPase c subunit.” BUFFALO, NY- August 15, 2024 –… read more

Oncotarget

HER2-low and HER2-zero in Breast Cancer Between Prognosis, Prediction and Entity

July 16, 2024

“[...] we found an independent positive prognostic effect of HER2-low compared to HER2-zero in early breast cancer.” BUFFALO, NY- July 16, 2024 – A new editorial paper was published in… read more

Figure 2: Analysis of immune cell subsets during neoadjuvant therapy.

Oncotarget

Durvalumab and Tremelimumab Before Surgery in Patients With HR+/HER2-negative Breast Cancer

March 27, 2024

“[...] this trial was stopped early after 3 of the first 8 enrolled patients experienced immunotherapy-related toxicity or suspected disease progression [...]” BUFFALO, NY- March 27, 2024 – A new… read more

Figure 2: Immunoblot assessment of effects on cell-cycle, pro- and anti-apoptosis signaling events mediated by Sacituzumab govitecan plus platinum-based chemotherapeutics in human TNBC, SCLC, and UBC tumor-lines.

Oncotarget

Sacituzumab Govitecan Plus Platinum-based Chemotherapy in Breast, Bladder, and Lung Carcinomas

March 4, 2024

“[...] these results support the rationale and potential for favorable clinical outcomes of combining SG therapy with platinum-based chemotherapeutics in solid tumors.” BUFFALO, NY- March 4, 2024 – A new… read more

Figure 1: Trends in the annual numbers of publications.

Oncotarget

Melatonin and Carcinogenesis in Mice

December 18, 2023

“[...] murine models proved to be valuable and, in some cases, indispensable for advancing melatonin applications in oncology [...].” BUFFALO, NY- December 18, 2023 – A new research perspective was… read more

Oncotarget

Risk Factors for Long-Term Arm Morbidities Following Breast Cancer Treatments: A Systematic Review

December 11, 2023

“This review revealed 29 primary risk factors associated with arm morbidity after breast cancer treatment.” BUFFALO, NY- December 11, 2023 – A new review paper was published in Oncotarget's Volume… read more

Figure 5: The mediators of mitochondrial biogenesis are required for cancer spread. "Osteopontin induces mitochondrial biogenesis in deadherent cancer cells"

Oncotarget

Osteopontin Induces Mitochondrial Biogenesis in Deadherent Cancer Cells

December 4, 2023

“Here, we study the induction of mitochondrial biogenesis by Osteopontin variants in deadherent breast tumor cells.” BUFFALO, NY- December 4, 2023 – A new research paper was published in Oncotarget's… read more

Figure 2: The spectrum of pathogenic variants in the early-onset breast cancer cohort.

Oncotarget

Genetic Predisposition to Early Breast Cancer in Kazakh Women

November 22, 2023

“Our study may reveal previously uncharacterized population-specific variants that may increase the risk of BC in the Kazakh population.” BUFFALO, NY- November 22, 2023 – A new research paper was… read more

Oncotarget

The Uncharted Role of HER2 Mutant Alleles in Breast Cancer

November 6, 2023

“Our research study has demonstrated that poziotinib is highly potent in neratinib-resistant HER2 L755S lobular and ductal breast cancer models [...].” BUFFALO, NY- November 6, 2023 – A new editorial… read more

Figure 1: An overview of the endocannabinoid pathway and molecules tested in this study. breast cancer

Oncotarget

FAAH Inhibition Ameliorates Murine Breast Cancer

November 1, 2023

“Besides being the most common, breast cancer is also a leading cause of cancer death in women worldwide.” BUFFALO, NY- November 1, 2023 – A new research paper was published… read more