Breast Cancer Archives

Oncotarget News

Systemic Treatment for Brain Metastasis in HER2-Positive Advanced Breast Cancer

September 13, 2023

With these new drugs now available in clinical practice, we expect HER2+/HER2-low BC patients with BMs to live longer and to live better.”BUFFALO, NY- September 13, 2023 – A... read more

Figure 1: Graphical representation of AIB1Δ4 enabling DCIS invasion and metastasis.

Oncotarget

Subpopulations of AIB1-Expressing Breast Cancer Cells Enable Invasion and Metastasis

September 6, 2023

The data in this paper suggest that even a small subpopulation of AIB1Δ4- expressing cells can enable cell invasion [...]” BUFFALO, NY- September 6, 2023 – A new editorial paper... read more

Oncotarget

Behind the Study: ER Expression Multiclonality in DCIS: Clinical & Future Insights

August 29, 2023

Dr. Mangesh A. Thorat from Guy’s Hospital in London, Queen Mary University of London, and King’s College London, describes a recent editorial he authored that was published by... read more

Oncotarget

A Macrophage is a Macrophage is a Macrophage—in Metastasis

August 23, 2023

We hope that these results will inform future attempts at anti-macrophage therapy and lead to better outcomes for patients in the not-too-distant future.” BUFFALO, NY- August 23, 2023 – A... read more

Oncotarget

Aggressive Luminal Breast Cancer: Are Cis-Spliced Fusion Proteins Pathological?

August 21, 2023

Our findings may provide a useful therapeutic approach for treating breast cancer patients who may suffer from early relapse and intrinsic resistance.” BUFFALO, NY- August 21, 2023 – A new... read more

Figure 1: Multi-clonal ER expression in DCIS.

Oncotarget

Multiclonality of Estrogen Receptor Expression in Ductal Carcinoma in Situ (DCIS)

August 1, 2023

We have discussed in detail the clinical implications of ER in avoiding overtreatment and undertreatment in DCIS.”BUFFALO, NY- August 1, 2023 – A new editorial paper was published in Oncotarget's... read more

Figure 1: An integrated representation of the multifaceted effects of progesterone in breast cancer.

Oncotarget

Deciphering Progesterone’s Mechanisms of Action in Breast Cancer

July 10, 2023

The mechanisms underlying the observed effects of progesterone on breast cancer outcomes are unclear.”BUFFALO, NY- July 10, 2023 – A new research perspective was published in Oncotarget's Volume 14 on... read more

Figure 1: Upon activation by the specific agonist LY500307 ERβ binds to estrogen receptor binding elements (ERE) in regulatory regions of GPR141 and ELMO1 genes and suppresses their transcription, which in turn leads to diminished RhoC activation, reduced actin-based cell migration and metastasis.

Oncotarget

ERβ as a Mediator of Estrogen Signaling in Inflammatory Breast Cancer

July 3, 2023

The mechanism of the anti-metastatic activity of ERβ was investigated [...]”BUFFALO, NY- July 3, 2023 – A new editorial paper was published in Oncotarget's Volume 14 on June 12, 2023, entitled, “... read more

Figure 1: Proposed pathway of ACSL4-mediated stimulation of quadruple negative breast cancer cells

Oncotarget

ACSL4: Biomarker, Mediator and Target in Quadruple Negative Breast Cancer

June 14, 2023

ACSL4 has been demonstrated to play a pivotal role in both normal physiology as well as in a variety of disease states, including breast and other cancers.”BUFFALO, NY- June... read more

Association of mutation and expression of the brother of the regulator of imprinted sites (BORIS) gene with breast cancer progression

Oncotarget

BORIS Gene Mutation and Expression: Link to Breast Cancer Progression

June 5, 2023

The current study analyzed the correlation between BORIS mutations and the expression of the protein in breast cancer cases.”BUFFALO, NY- June 5, 2023 – A new research paper was published... read more