Tag: cancer research

Targeting Ras With Protein Engineering

November 27, 2023

“While Ras’s relationship to cancer has been long established [37], it has been considered an undruggable target for many years.” BUFFALO, NY- November 27, 2023 – A recent review paper… read more

Figure 2: The spectrum of pathogenic variants in the early-onset breast cancer cohort.

Oncotarget

Genetic Predisposition to Early Breast Cancer in Kazakh Women

November 22, 2023

“Our study may reveal previously uncharacterized population-specific variants that may increase the risk of BC in the Kazakh population.” BUFFALO, NY- November 22, 2023 – A new research paper was… read more

Figure 1: Chromatin landscape of the glioma GWAS locus rs55705857 in the melanocyte lineage.

Oncotarget

Predicting the Molecular Functions of Regulatory Genetic Variants Associated With Cancer

November 20, 2023

“Effectively integrating these rich resources with GWAS results will continue to help prioritize causative inherited genetic variants and improve our molecular understanding of disease etiology [...]” BUFFALO, NY- November 20,… read more

Oncotarget

Obesity Paradox and Lung Cancer, Metformin-based Therapeutic Opportunity?

November 15, 2023

“These findings suggest a strong sensitization by the addition of metformin in obese population, suggesting that biochemical and molecular differences influence the treatment response.” BUFFALO, NY- November 15, 2023 –… read more

Oncotarget

C/EBPβ Cooperates With MYB to Maintain the Oncogenic Program of AML Cells

November 13, 2023

“This makes C/EBPβ an interesting pro-oncogenic player in AML, worthy of further studies.” BUFFALO, NY- November 13, 2023 – A new editorial perspective was published in Oncotarget's Volume 14 on… read more

Figure 1: Graphical illustration of the main findings from Pfeiffer et al., Cancer Research, 2022. Combined Inhibition of SHP2 and Mutated RTKs Prevent Acquired Resistance in Leukemia

Oncotarget

Combined Inhibition of SHP2 and Mutated RTKs Prevent Acquired Resistance in Leukemia

November 8, 2023

“In summary, this study reveals a molecular escape mechanism of mutated RTK-driven leukemic cells from SHP2 allosteric inhibition [...]” BUFFALO, NY- November 8, 2023 – A new editorial paper was… read more

Oncotarget

The Uncharted Role of HER2 Mutant Alleles in Breast Cancer

November 6, 2023

“Our research study has demonstrated that poziotinib is highly potent in neratinib-resistant HER2 L755S lobular and ductal breast cancer models [...].” BUFFALO, NY- November 6, 2023 – A new editorial… read more

Figure 1: An overview of the endocannabinoid pathway and molecules tested in this study. breast cancer

Oncotarget

FAAH Inhibition Ameliorates Murine Breast Cancer

November 1, 2023

“Besides being the most common, breast cancer is also a leading cause of cancer death in women worldwide.” BUFFALO, NY- November 1, 2023 – A new research paper was published… read more

Figure 1: Mechanisms involved in regulation of tumor progression by neutrophil PAD4.

Oncotarget

Neutrophil PAD4: How Does it Function in Cancer Beyond Promoting NETosis?

October 30, 2023

“This will open a novel therapeutic approach for targeting PMN-MDSC in cancer.” BUFFALO, NY- October 30, 2023 – A new editorial paper was published in Oncotarget's Volume 14 on March… read more

Figure 4: Loss of p53 predisposes to mammary tumors in mice and in women, but penetrance varies among individuals.

Oncotarget

Genetic Modifiers of p53 and Their Potential in Breast Cancer Therapies

October 25, 2023

“[...] p53 acts in concert with other genes that alter the penetrance of tumor phenotypes and the modifiers differ among tissues.” BUFFALO, NY- October 25, 2023 – A new editorial… read more