Tag: cancer research

Figure 1: Inhibitors of mitochondrial respiration.

Targeting Cellular Respiration as a Therapeutic Strategy in Glioblastoma

May 19, 2023

“Here, we provide a brief overview of the status quo of targeting mitochondrial energy metabolism in glioblastoma and highlight a novel combination therapy.” Listen to an audio version of this… read more

Figure 2: Polyclonal, Clonal and Restricted Repertoire Phenotypes in Clonality Testing.

Oncotarget

Automated, Accurate Reporting for NGS-Based Clonality Testing

May 16, 2023

“[...] we have developed a fully automated calling algorithm for determining B and T cell clonality from NGS [next-generation sequencing] data, with greater sensitivity than previously developed models.” Listen to… read more

Figure 3: Combined analysis of kinase expression in tumors with cell line dependency to identify new gene targets. therapeutic targeting

Oncotarget

Using Cancer Proteomics Data to Identify Gene Candidates for Therapeutic Targeting

May 10, 2023

“[...] we consider some public molecular resources, including proteomics datasets, that may be leveraged to help identify gene candidates for therapeutic targeting in cancer.” Listen to an audio version of… read more

Oncotarget

Behind the Study: Role of Biomarkers in Management of Lumps in the Breast

May 10, 2023

Dr. Georg F. Weber, from the University of Cincinnati Academic Health Center, describes a recent research perspective he authored that was published by Oncotarget in Volume 14, entitled, “Crossroads: the… read more

Figure 2: Comparison of human LY6 gene expression in normal uterine tissue (n = 146) to expression in uterine corpus endometrial carcinoma (n = 547).

Oncotarget

LY6 Gene Family: Potential Tumor Antigens and Prognostic Biomarkers in Endometrial Cancer

May 8, 2023

“Importantly, the expression of several LY6 genes is elevated in UCEC [uterine corpus endometrial carcinoma] when compared to the expression in normal uterine tissue.” Listen to an audio version of… read more

Oncotarget

Systemic AL Amyloidosis: Current Approach and Future Direction

May 5, 2023

“AL amyloidosis is a fatal disease and systemic therapy is required to prevent deposition of amyloid in other organs and prevent progressive organ failure.” Listen to an audio version of… read more

Figure 1: Retinol-mediated suppression of tumor-promoting IL-6 is disrupted in colon cancer-associated fibroblasts.

Oncotarget

Retinol Disruption and the Role of Vitamin A Metabolism in Colon Cancer

May 3, 2023

“Retinoids are known to inhibit tumor-promoting IL-6 production.” Listen to an audio version of this press release BUFFALO, NY- May 3, 2023 – A new research perspective was published in… read more

Oncotarget

Crossroads: The Role of Biomarkers in the Management of Lumps in the Breast

May 2, 2023

“A biomarker or set of biomarkers to inform on the individual progression risk would be beneficial to the patient and cost-effective for the healthcare system.” Listen to an audio version… read more

Figure 3: Cytokine expression and cell viability upon mRNA silencing of STAT3 isoforms

Oncotarget

Differential Silencing of STAT3 Isoforms Leads to Changes in STAT3 Activation

April 26, 2023

“Our study emphasizes the importance of distinguishing between STAT3α and STAT3β proteins and their active forms when discussing STAT3-related cancer diagnosis and therapy.” Listen to an audio version of this… read more

Figure 1: Tumor necroptosis promotes metastasis of breast cancer by suppressing anti-tumor immunity.

Oncotarget

Tumor Necroptosis Promotes Metastasis by Modulating Tumor-Host Immunity

April 25, 2023

“[...] we found that blocking necroptosis leads to the inhibition of metastasis in mouse breast cancer models [...]” Listen to an audio version of this press release BUFFALO, NY- April… read more