Tag: cancer research

Figure 4: Everolimus reduces microvessel density (MVD) and lymphatic vessel density (LVD) in TP53 mutant HNSCC xenografts.

Oncotarget | Everolimus Inhibits Angiogenesis and Lymphangiogenesis in TP53 Mutant HNSCC by Downregulating STAT3/HIF-1α/VEGF Pathway

February 9, 2023

“[...] we sought to investigate the mechanism for everolimus-induced inhibition of TP53 HNSCC.” Listen to an audio version of this press release BUFFALO, NY- February 9, 2023 – A new… read more

Figure 1: Multiple mechanisms underly the pro-tumorigenic role of CD200.

Oncotarget

Oncotarget | Immunoregulatory Protein CD200 as Potentially Lucrative Yet Elusive Target for Cancer Therapy

February 7, 2023

“CD200 expression is reported across most cancer types [...]” Listen to an audio version of this press release BUFFALO, NY- February 7, 2023 – A new research perspective was published… read more

Figure 2: Kaplan–Meier curve for estimated median DOR in the DLBCL combined cohort (response-evaluable population).

Oncotarget

Oncotarget | Mivavotinib for Relapsed/Refractory B-cell Lymphoma (Updated)

February 1, 2023

“The current analysis provides updated results for these lymphoma patients with extended follow-up.” Listen to an audio version of this press release BUFFALO, NY- February 1, 2023 – A new… read more

Figure 1: Putative mechanisms of toxicity. immunovirotherapy

Oncotarget

Oncotarget | Intraventricular Immunovirotherapy; A Translational Step Forward

January 26, 2023

“Immunotherapies, including oncolytic virotherapy, offer novel, targeted approaches to treat brain tumors with increased efficacy and reduced toxicity [5].” Listen to an audio version of this press release BUFFALO, NY-… read more

Figure 2: Histopathological evaluation of oral mucositis on days 4, 8, 12 and 15. (truncated)

Oncotarget

Oncotarget | The Chromatographic Constitution of Andiroba Oil and its Healing Effects…

January 24, 2023

“The andiroba extract in wounds provides acceleration in healing process, with increase of contraction rate and local re-epithelialization, resulting in the complete closure of wounds [52].” Listen to an audio… read more

Figure 3: STRO-001 showed potent cell killing activity on proliferating primary human B cells.

Oncotarget

Oncotarget | Targeting CD74 in B-cell Non-Hodgkin Lymphoma With Antibody-Drug Conjugate STRO-001

January 17, 2023

“Taken together, these findings provide a strong rationale for potently and selectively targeting of CD74 in patients with B-NHL [B-cell non-Hodgkin lymphoma].” Listen to an audio version of this press… read more

Figure 7: Proposed mechanism of 15d-PMJ2-mediated apoptosis.

Oncotarget

Oncotarget | Calcium Signaling Induced by 15-deoxy-prostamide-J2 Promotes Cell Death by Activating…

January 12, 2023

“The goal of the present study was to determine the therapeutic potential of 15d-PMJ2 against melanoma by gaining insight into molecular mechanisms underlying its apoptotic activity.” Listen to an audio… read more

Figure 1: Demographic factors, comorbidities and therapy regime of the melanoma patients in percentage, age in years.

Oncotarget

Oncotarget | Impact of Covid-19 on Management of Patients With Metastatic Melanoma

January 11, 2023

“In this study, we aimed to analyze our experience with patients suffering from Sars-CoV-2 infection while receiving treatment for metastatic melanoma.” BUFFALO, NY- January 11, 2023 – A new research… read more

Figure 4: Wnt pathway expression in tumors from NeuT/ATTAC mice.

Oncotarget

Oncotarget | Resistance of MMTV-NeuT/ATTAC Mice to Anti-PD-1 Immune Checkpoint Therapy is Associated With Macrophage Infiltration and Wnt Pathway Expression

January 5, 2023

“One of the impediments to successful cancer therapy is the heterogeneity and cellular plasticity of the tumor and TME [22, 23].” Listen to an audio version of this press release… read more

Oncotarget

Oncotarget | Serum microRNAs as New Criteria for Referral to Early Palliative Care Services in Treatment-Naïve Advanced Cancer Patients

December 29, 2022

“The most important finding was the development of an objective prediction model for patients admitted to a PCU within 6 months among treatment-naïve advanced cancer patients.” — Listen to an… read more