Tag: cancer research

SETDB1 Amplification Identified as a Potential Target for New Osteosarcoma Treatment

February 14, 2025

“Our team has demonstrated the presence of SETDB1 abnormalities, particularly its amplification, through WES analysis of osteosarcoma human samples and cell lines.” BUFFALO, NY - February 14, 2025 – A… read more

Oncotarget

Rare Case of Donor Cell-Derived Blood Cancer Discovered Nine Years After Stem Cell Transplant

February 10, 2025

“An uncommon side effect of allogeneic hematopoietic cell transplantation is donor cell-derived hematologic neoplasm (DCHN), which develops when donor hematopoietic cells undergo oncogenic transformation.” BUFFALO, NY - February 10, 2025… read more

Oncotarget

HER2-Low Breast Cancer: Genomic Insights and Evolving Treatment Paradigms

January 22, 2025

“Human epidermal growth factor receptor 2 (HER2)-low breast cancer has recently emerged as a new clinical subtype of breast cancer, benefiting from treatment with novel anti-HER2 antibody-drug conjugates.” BUFFALO, NY… read more

Oncotarget

Anti-Correlation Between KLRG1 and PD-1 in Tumor CD8 T Cells

January 21, 2025

“The anti-correlation of PD-1 and KLRG1 expression in human tumor infiltrating CD8 T cells suggests the potential for combination therapy supra-additive benefits of anti-PD-1 and anti-KLRG1 therapies.” BUFFALO, NY -… read more

Oncotarget

Pitfalls of FDA-Approved Germline Cancer Predisposition Tests

December 30, 2024

“The FDA approval on September 29, 2023, for 'class III de novo' blood tests to assess hereditary cancer risk make widely available tests that may be obtained through a Direct… read more

Oncotarget

Breakthroughs in Cell-Penetrating Monoclonal Antibody Therapies

December 11, 2024

“Monoclonal antibodies (mAb) have emerged as a promising tool in advancing personalized medicine.” BUFFALO, NY - December 11, 2024 – A news feature on the research paper “Next-generation cell-penetrating antibodies… read more