Oncotarget.net features press releases on the latest oncology research, as well as interviews from the distinguished network of authors who continue to publish their research with Oncotarget.

Tag: p53

Oncotarget

New Hypothesis Links HPV E6 and SARS‑CoV‑2 Spike Proteins to Reduced p53 Activity

January 13, 2026

“Thus, the present hypothesis is that virally encoded proteins such as HPV-E6 or SARS-COV-2 Spike may cooperate in suppressing host defenses including tumor suppressor mechanisms involving p53.” BUFFALO, NY -… read more

Oncotarget

Researchers Identify New p53 Targets to Combat Cancer Growth

February 24, 2025

"We discovered several novel downstream p53 targets of potential clinical relevance [...]” BUFFALO, NY - February 24, 2025 – A new research paper was published in Oncotarget, Volume 16, on… read more

Oncotarget

ISR Activation & Apoptosis via HRI Kinase by PG3 and Other p53 Cancer Therapies

September 18, 2024

“Our results provide unique insights into the mechanism of action of PG3 as a novel cancer therapeutic targeting p53 pathway-like tumor suppression.” BUFFALO, NY- September 18, 2024 – A new… read more

Figure 4: Loss of p53 predisposes to mammary tumors in mice and in women, but penetrance varies among individuals.

Oncotarget

Genetic Modifiers of p53 and Their Potential in Breast Cancer Therapies

October 25, 2023

“[...] p53 acts in concert with other genes that alter the penetrance of tumor phenotypes and the modifiers differ among tissues.” BUFFALO, NY- October 25, 2023 – A new editorial… read more

Figure 7: Schematic demonstrating the role of GPR141 in mediating breast cancer development and progression.

Oncotarget

GPR141 Regulates Breast Cancer Progression via Oncogenic Mediators and The p-mTOR/p53 Axis

May 22, 2023

“This research uncovers GPR141 as a stimulator of breast tumorigenesis and metastasis, making it a candidate target for breast cancer therapeutics.” Listen to an audio version of this press release… read more

Oncotarget

Oncotarget | Genomic Alterations Predictive of Poor Clinical Outcomes in Pan-cancer

October 4, 2022

PRESS RELEASE: A new research paper was published in Oncotarget's Volume 13 on September 28, 2022, entitled, “Genomic alterations predictive of poor clinical outcomes in pan-cancer.” Listen to an audio… read more