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FOXM1 and PD-L1 in CDK4/6-MEK Resistance in Nerve Tumors

October 1, 2024

We suggest that future therapeutic strategies targeting the oncogenic network of CDK4/6, MEK, PD-L1, and FOXM1 represent exciting future treatment options for MPNST patients.”BUFFALO, NY- October 1, 2024 –... read more

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Disrupting NKG2A:HLA-E Interactions for Enhanced Anti-Cancer Immunity

August 21, 2024

there is strong preclinical evidence that disruption of NKG2A interactions with HLA-E can stimulate both NK cell and cytotoxic T cell effector functions against cancer.”BUFFALO, NY- August 21, 2024 –... read more

Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival

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TCR CDR3s and Renalase-1 Linked to Increased Melanoma Survival

August 8, 2024

These findings indicate that renalase-1 is a potential antigen for TCR recognition in melanoma and could be considered as a target for immunotherapy.”BUFFALO, NY- August 8, 2024 – A new... read more

INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment and induction of immunogenic cell death

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INT-1B3 miR-193a-3p Mimic Boosts T Cell Immunity and Induces Tumor Cell Death

August 5, 2024

INT-1B3 inhibited distant tumor metastasis and significantly prolonged survival.”BUFFALO, NY- August 5, 2024 – A new research paper was published in Oncotarget's Volume 15 on July 12, 2024, entitled, “INT-1B3,... read more

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Testimonial: Dr. John Hawse

October 8, 2021

Below is a transcript of the testimonial by Dr. John Hawse from the Mayo Clinic in Rochester, MN, about the experience publishing his research paper, "ERβ inhibits cyclin dependent kinases... read more

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Behind the Study: Populations of Cells Resistant to EMT

September 27, 2021

Dr. Herbert Levine and Dr. Mohit Kumar Jolly describe their research that was published by Oncotarget on July 7, 2020, entitled, “Epigenetic feedback and stochastic... read more

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Behind the Study: Evaluations in TRAMP Prostate Cancer Model

September 20, 2021

Behind the Study is a series of transcribed videos from researchers elaborating on their oncology-focused studies published by Oncotarget. A new Behind the Study is released each Monday.... read more

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Oncotarget Podcast Episodes: The Latest in Oncology-Focused Research

February 24, 2021

Hundreds of scientific studies, reviews, and analyses are being published from around the world at any given time. This can make reading the latest research literature a time consuming task—... read more

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Special Collections by Oncotarget: Prostate Cancer

February 11, 2021

Prostate cancer, or prostatic carcinoma, occurs in a small walnut-shaped gland in males that is responsible for producing the seminal fluid which nourishes and transports sperm—the prostate. Symptoms of... read more

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Special Collection by Oncotarget: Lung Cancer

December 11, 2020

Lung cancer is still the leading cause of cancer-related mortality worldwide. According to the CDC, smoking cigarettes is linked to 80-90% of lung cancer deaths in the United States. In... read more