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Oncotarget News

New Compound Disrupts Survival Pathways in Aromatase Inhibitor-Resistant Breast Cancer Cells

August 13, 2025

The ability of PCAIs to mitigate various cancer hallmarks in the various cancer cell lines has been well established.”BUFFALO, NY - August 13, 2025 – A new research paper was published... read more

Oncotarget

Comprehensive Genomic Testing Reveals Treatment Targets in 90% of Advanced Solid Tumors

July 29, 2025

The broad capabilities of the OncoExTra assay detected therapeutically actionable and other clinically relevant genomic events that can inform clinical decision-making for patients with advanced solid tumors.”BUFFALO, NY - July... read more

Oncotarget

Cholesterol-Lowering Drugs Show Promise Against Colorectal Cancer

July 22, 2025

Our findings provide direct evidence that statins selectively modulate key components of the Wnt/β-catenin signaling pathway, a major driver of adenoma formation, including members of the special AT-rich sequence-binding (... read more

Oncotarget

New Antibody Selectively Targets Immune Cells That Suppress Anti-Tumor Responses

July 16, 2025

Taken together, our studies suggest that 2B010 represents an anti-CD25 mAb with unique properties in that it deleted Treg from an inflammatory environment (GVHD) as well as from the TME.”... read more

Oncotarget

EGFR-Targeted Therapy Resistance in Breast and Head & Neck Cancers

July 9, 2025

By synthesizing current insights on both RTK and non-RTK mediated resistance against anti-EGFR therapies, this review aims to guide future research and improve therapeutic strategies for these cancers.”BUFFALO, NY -... read more

Oncotarget

New Drug Combination Redefines First-Line Treatment for Advanced Urothelial Cancer

July 1, 2025

Recent developments have introduced promising therapies, notably the combination of enfortumab vedotin with pembrolizumab, which is now recommended as the first-line therapy following the EV-302 trial results.”BUFFALO, NY - July... read more

Oncotarget

WIN International Molecular Tumor Board Recommends Tailored Treatment for Advanced Colorectal Cancer

June 24, 2025

This case emphasizes the critical role of comprehensive molecular profiling and personalized therapeutic approaches in managing complex mCRC.”BUFFALO, NY - June 24, 2025 – A new precision oncology paper was published... read more