Author: Kathryn Atkins

Cancer-Associated Fibroblasts: Challenges and Opportunities

April 5, 2023

“Beyond detection of cancer, CAFs are being actively pursued as targets for therapy.” Listen to an audio version of this press release BUFFALO, NY- April 5, 2023 – A new… read more

Figure 1: The molecular mechanism(s) of how Wnt5a signaling could (i) induce ROR1 and cortactin association, tyrosine phosphorylation of cortactin, and activation of RhoA, (ii) enhance F-actin polymerization, and (iii) subsequently promote migration or metastasis of cancer cells.

Oncotarget

Impact of Cortactin in Cancer Progression

April 4, 2023

“Cortactin (also known as EMS1 or CTTN) is expressed broadly in a variety of cancers [...]” Listen to an audio version of this press release BUFFALO, NY- April 4, 2023… read more

Oncotarget

Oncotarget at AACR Annual Meeting 2023

April 4, 2023

Impact Journals (Oncotarget's publisher) is proud to participate at the American Association for Cancer Research (AACR) Annual Meeting 2023, which convenes April 14-19 in Orlando, Florida. Listen to an audio version of… read more

Figure 7: Effects of TGF-β receptor inhibitor EW7197 with and without TGF-β1 for LSR, TRIC, OCLN, and CLDN-2 in human lung epithelial cells (HLE) cells with and without 10% FBS.

Oncotarget

Downregulation of Angulin-1/LSR Induces Malignancy in Lung Adenocarcinoma

March 29, 2023

“In the present study, we found that downregulation of angulin-1/LSR induced malignancy via upregulation of EGF-dependent CLDN-2 and TGF-β-dependent cell metabolism in human lung adenocarcinoma.” Listen to an audio version… read more

Figure 5: NSL-YHJ-2-27 suppresses cancer cell migration and invasion.

Oncotarget

Oncotarget | Polyisoprenylated Cysteinyl Amide Inhibitors Deplete G-Proteins in Cancer Cells

March 28, 2023

“[...] mutations in G-proteins have been associated in the progress of several cancers [...]” Listen to an audio version of this press release BUFFALO, NY- March 28, 2023 – A… read more

Figure 6: Overexpression of GPC1 increases proliferation of T24 cells.

Oncotarget

Oncotarget | Attenuation of Cancer Proliferation by Suppression of Glypican-1

March 22, 2023

“This study was designed to increase the knowledge on the potential of GPCs and in particular GPC1 as a biomarker in cancer diagnosis and prognosis.” Listen to an audio version… read more

Oncotarget

Oncotarget | Unlocking the Potential of Molecular-Driven Stratification of Osteosarcoma

March 20, 2023

“We are very enthusiastic about these initiatives and the recent rate of discoveries in OSA, and hopeful that they will bring actionable targets for OSA.” Listen to an audio version… read more

Figure 1: Mechanism of action of MTAP along with downstream effects from its loss.

Oncotarget

Oncotarget | MTAP Loss in Metastatic Breast Cancer Patients: Genomic Landscape

March 14, 2023

“In breast cancer, MTAP downregulation activates ornithine decarboxylase (ODC) which in turn leads to formation of putrescine which promotes tumor migration, invasion and angiogenesis [15].” Listen to an audio version… read more

Figure 6: Synergistic/antagonistic combinations.

Oncotarget

Oncotarget | Selective Protection of Normal Cells From Chemotherapy, While Killing Drug-Resistant Cancer Cells

March 13, 2023

“Selective protection of normal cells may transform therapy of cancer.” Listen to an audio version of this press release BUFFALO, NY- March 13, 2023 – A new review paper was… read more

Oncotarget

Oncotarget | Mitochondria Engage the Integrated Stress Response to Promote Tumor Growth

March 8, 2023

“Overall, this research proposes a new paradigm on how AR-independent PCa can drive tumor traits by exploiting mitochondrial signaling pathways [...]” Listen to an audio version of this press release… read more