Tag: Breast Cancer

Figure 5: NSL-YHJ-2-27 suppresses cancer cell migration and invasion.

Oncotarget | Polyisoprenylated Cysteinyl Amide Inhibitors Deplete G-Proteins in Cancer Cells

March 28, 2023

“[...] mutations in G-proteins have been associated in the progress of several cancers [...]” Listen to an audio version of this press release BUFFALO, NY- March 28, 2023 – A… read more

Figure 1: Mechanism of action of MTAP along with downstream effects from its loss.

Oncotarget

Oncotarget | MTAP Loss in Metastatic Breast Cancer Patients: Genomic Landscape

March 14, 2023

“In breast cancer, MTAP downregulation activates ornithine decarboxylase (ODC) which in turn leads to formation of putrescine which promotes tumor migration, invasion and angiogenesis [15].” Listen to an audio version… read more

Oncotarget

Oncotarget | Extreme Phenotype Approach Identifies Rare ATR Variants as Potential Male Breast Cancer Susceptibility Alleles

February 21, 2023

“Basic functions of ATR classify it in the category of tumor suppressor genes but further studies show that its role is more complex in the context of cancer.” Listen to… read more

Figure 4: Wnt pathway expression in tumors from NeuT/ATTAC mice.

Oncotarget

Oncotarget | Resistance of MMTV-NeuT/ATTAC Mice to Anti-PD-1 Immune Checkpoint Therapy is Associated With Macrophage Infiltration and Wnt Pathway Expression

January 5, 2023

“One of the impediments to successful cancer therapy is the heterogeneity and cellular plasticity of the tumor and TME [22, 23].” Listen to an audio version of this press release… read more

“Association of fall rate and functional status by APOE genotype in cancer survivors after exercise intervention.”

Oncotarget

Behind the Study: APOE Genotype Determines Cancer Patients Most Likely to Benefit From Exercise

December 13, 2022

Dr. Kerri Winters-Stone and Dr. Jacob Raber from Oregon Health and Science University, describe a research paper they co-authored that was published by Oncotarget in Volume 13, entitled, “Association of… read more

Oncotarget

Oncotarget | Association of Fall Rate and Functional Status by APOE Genotype in Cancer Survivors After Exercise Intervention

November 21, 2022

“This is the first examination of the relationship among exercise, apoE genotype, and side effects and symptoms of cancer in a subset of older female cancer survivors participating in a… read more

Oncotarget

Oncotarget | Therapeutic Efficacy of Humanized JAA-F11 Anti-Thomsen-Friedenreich Antibody Constructs H2aL2a and H3L3 in Human Breast and Lung Cancer Xenograft Models

October 25, 2022

“The potential therapeutic efficacy of the humanized antibodies to TF-Ag-α, hJAA-F11-H2aL2a and hJAA-F11-H3L3, was assessed in human breast and lung cancer xenograft models.” Listen to an audio version of this… read more

Oncotarget

Behind the Study: Inhibition of Resistant Triple-negative Breast Cancer Cells

September 19, 2022

Dr. Balraj Singh from the University of Texas MD Anderson Cancer Center, describes a recent research paper he co-authored that was published by Oncotarget, entitled, “Inhibition of resistant triple-negative breast… read more

Oncotarget

Oncotarget | Role of germline variants in the metastasis of breast carcinomas

July 7, 2022

“We found several gene candidates through which the host’s genetic makeup contributes to metastasis.” Listen to an audio version of this press release BUFFALO, NY- July 7, 2022 – A… read more

Oncotarget

Oncotarget | Continuous Treatment With Abemaciclib Leads to Sustained and Efficient Inhibition of Breast Cancer Cell Proliferation

July 6, 2022

“These preclinical results support the unique efficacy and safety profile of abemaciclib observed in clinical trials.” Listen to an audio version of this press release BUFFALO, NY- July 6, 2022… read more